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Differences of electroacupuncture-induced analgesic effect in normal and inflammatory conditions in rats. Am J Chin Med 2003;31(6)955-965. 5772/55184 [37] Chen WH, Hsieh CL, Huang CP, et al. Acid-sensing ion channel 3 mediates peripher‐ al anti-hyperalgesia effects of acupuncture in mice inflammatory pain. J Biomed Sci 2011;1882. [38] Groth R, Aanonsen L. Spinal brain-derived neurotrophic factor (BDNF) produces hy‐ peralgesia in normal mice while antisense directed against either BDNF or trkB, pre‐ vent inflammation-induced hyperalgesia.

Fur‐ thermore, it is highly controversial whether acupuncture used in animals and humans is ex‐ actly the same in regard to physiological and anatomical considerations, and findings obtained only in animal studies may be of limited significance [3]. Thus, to demonstrate the 36 Acupuncture in Modern Medicine involvement of NO in the acupuncture mechanism, evidence obtained with human subjects is absolutely necessary. Our laboratory has been investigating traditional medicine from the standpoint of Western medicine and basic science, and has also extensively studied reactive oxygen species (ROS) and NO metabolism in various physiological and pathological conditions [9, 10].

Relationship between PaO2 and exhaled NO. Exhaled air samples were collected from 23 healthy subjects using a slow vital capacity maneuver. 65). 4. Interpretation Our findings indicate that exhaled airway NO is involved in arterial oxygenation in the res‐ piratory system. This is not surprising when considering the potent effects of NO on vascu‐ lar and/or airway smooth muscular tone, which may control ventilation-to-perfusion matching in the respiratory system. Theoretically, NO concentrations in respiratory gas ex‐ change are not equal throughout the respiratory zone, as they are dependent on the amount of inspirable NO generated in the upper airway in addition to intrinsic NO generated in the lower respiratory zone.

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